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R is a free software environment for statistical computing and graphics. It compiles and runs on a wide variety of UNIX platforms, Windows and MacOS. To download R, please click on this link and choose your preferred CRAN mirror.

The package Multistate have been developped to implement multistate models. We propose functions implementing 3-state and 4-state models such as Semi-Markov (SM) models (modelling the probabilities of transitions according to the times spent in states) and time-inhomogenous Markov models (modelling the probabilities of transitions according to the chronological times). We also propose to take into account the mortality of the general population (relative survival approach).
The methods proposed are limited to parametric models. Estimation of the parameters is based on maximum likelihood.

As an example, we proposed a data frame with the data extracted from the DIVAT data bank with a multistate possible evolution of the clinical status of kidney transplant recipients.

Download the Multistate package and save the resulting file to your machine

Install the Multistate package

  • Shut down R if it is running.
  • Using a command-line window navigate (using the "cd" command) to the directory where you saved the file and issue the command: sudo R CMD INSTALL Multistate_0.x.tar.gz.
  • Shut down R if it is running.
  • Restart R from the Start Menu.
  • From the Packages menu, choose the Install package(s) from local zip files.
  • Navigate to and choose the file you just downloaded:
If you find any bugs in Multistate package, please e-mail us and we will take your comments into account in the next version.